Mumbai's KEM & Nair Hospitals prepare to initiate Phase 3 trials of Oxford Covid-19 vaccine

The two hospitals are in the last leg of Phase 2 Clinical trials and expect the 3rd Phase to kickstart by December first week

Mumbai has buckled up in the pursuit of developing a vaccine against coronavirus and to achieve this goal, the BYL Nair Hospital and King Edward Memorial (KEM) Hospital are preparing to authenticate the phase 3 clinical trials of Oxford's Covishield vaccine by the first week of December. At present, the two medical institutions are in the last leg of phase 2 trials, which will conclude by next week.


Mumbai hospitals prepare for phase 3 trails in December

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The Indian Council of Medical Research had prescribed the phase 2 and phase 3 trial procedures of the Oxford COVID-19 vaccine to the KEM and Nair Hospital in Mumbai, and these centres have incubated about 195 and 148 volunteers into the dual-step process, respectively. According to the guidelines issued by the ICMR, volunteers need to be given two dosages of the vaccine, 28 days apart.

Post this, the hospitals can only jump onto the next( third) phase after a break of 28 days, with approval from the Central Drugs Standard Control Organisation (the national regulatory body for medicines). The Medical officials at the two institutes have agreed to conduct the third phase trials on the same volunteers, in order to obtain a conclusive report and impact, post a full dose.

The Vaccine Response

Post the first phase of Covishield's clinical trials, volunteers exhibited a strong immune response. This vaccine stimulates a T cell (white blood cells that can attack cells infected with the coronavirus) response within 2 weeks time, and an provokes an antibody response within 28 days approximately.

Covishield protoype from Oxford, United Kingdom will be jointly manufactured by the Pune-based Serum Institute of India (SII), the world's largest manufacturer of vaccines in terms of volume, and British-Swedish pharmaceutical giant AstraZeneca.

Knock Knock

The recovery has boomed past the tally of 2,72,455 with 10,627 deaths. The successful trials and the partnered manufacturing of the Covishield will bring a huge respite to the city of Mumbai, which added about 924 new cases to the total caseload on Thursday, taking the count of active cases up to the mark of 11,694. This immune-boosting process will also improve the city's recuperation rate which currently stands 91.5% with 2,49,357 recoveries.

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