The two-drug concoction was given to 212 patients above the age of 12 in Mumbai and the results were encouraging.
The Brihanmumbai Municipal Corporation on Monday stated their 'Antibodies Cocktail Treatment' has proven effective against the coronavirus infection. The concoction drug has worked wonders in the trial conducted recently for a sample group of 212 patients above the age of 12. A pilot project, the 'Antibody Cocktail Therapy' evoked a positive response in about 199 of the subject pool.
First successful trial of 'cocktail therapy' can revolutionise COVID treatment
Mumbai's civic body has created a mixture-medicine by combining two drugs - Casirivimab and Indevimab, both manufactured by the pharma giant Roche India, to provide the 'Antibodies Cocktail Therapy'. The first trials of this new drug have shown a revolutionary response in a majority of patients, roped in for the trial.
"The patients were selected carefully, with their weight above 40 kg, with mild-to-medium symptoms of Covid-19, and at least one co-morbidity condition. They were administered the 'antibodies cocktail' for an hour through saline under medical supervision," informed Severn Hills Hospital's Dean, Dr Balkrishna Adsul.
Reportedly, none of these patients has exhibited any adverse reaction or side effects to the medicine. The patients' body temperature(fever) dropped to normal within 48 hours and the death rate has fallen steeply by 70%. As yet, only one patient of this pool required oxygen supports even after drug consumption, he added.
Pilot results look promising ahead of 'third wave' rise
"Besides, their hospital stay was reduced to barely 5-6 days from the current 14-15 days and we can also give this 'antibody cocktail' to patients as OPD, without needing admission to the hospital," Adsul said. The trial procedure was implemented during the past four weeks.
"Most importantly, it can be administered to patients having diabetes, patients dealing with diabetes, high blood pressure, kidney problems, heart diseases, asthma and other acute respiratory diseases, sickle cell, cerebral palsy among other comorbidities", the Dean added. Successive trials will be conducted for the cocktail therapy, which officials believe can alter the scope and effectiveness of COVID treatment, aiding the management of the potential third wave.
BMC asks public hospitals to administer cocktail therapy for 1-2 months
The antibody cocktail therapy is presently being used clinically for third-stage or terminal cancer treatment. And it now looks promising for the treatment of coronavirus too. The assuring conclusions of the pilot project have given authorities the confidence to direct several civic hospitals and medical colleges to administer the new treatment blend to COVID-19 patients over the next month or two.
After this, medical experts will engage in a study of the trial outcome and publish a research paper as medical proof of the treatment effectiveness. The civic and state health departments would thereafter take necessary steps in the matter. Reportedly, with the 'antibody cocktails' arsenal, BMC officials are optimistic about claiming victory in the pandemic battle.