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The Indian Institute of Indore has made a great achievement in the field of medicine by developing an economical means to treat Acute Lymphoblastic Leukemia (ALL) with fewer side-effects. ALL is a type of blood cancer that can now be cured with the help of the new asparaginase- an enzyme cultured by IIT-Indore, using the protein engineering approach. About 25% of all cancer cases diagnosed in children mounting up to 25,000 cases each year, in India itself.


A new ray of hope after 12 years of research

Asparaginase is commonly used for the treatment of cancer, however, IIT-Indore has highlighted that the repeated use of this enzyme causes several side-effects in patients. These range from allergic reactions to neurotoxicity, immunogenicity, hypersensitivity and toxicity to the pancreas, liver, spleen among other organs - causing more harm than help.

As a result, there is a global search to find an asparaginase variant with a safer immunogenic profile than the current enzyme that hampers the treatment of leukemia. Achieving a milestone in this field, the Indian Institute of Indore, developed a new variant called the M-ASPAR asparaginase after 12 years of research. The primary aim was to develop an enzyme variant that could not only reduce grave side effects but also improve the overall primary treatment and relapse of ALL.

The Principal Investigator Professor Avinash Sonawane of Biosciences and Biomedical Engineering at IIT-Indore informed that is novel enzyme is less carcinogenic, causes fewer toxicities, including neurotoxicity. It is far more stable than the current asparaginase used for treatment and could kill leukemia cells.

IIT-Indore aces the field of research and medicine

The research team led by Professor Sonawane includes Dr Ranjit Mehta, Soumika Sengupta and Mainak Biswas pointed out that access to good quality asparaginase in India is a big problem despite being included in WHO's list of essential medicines. The same problem persists in several other Asian, African and South American countries as well.

IIT Indore joined hands with Advanced Centre for Treatment, Research and Education in Cancer and Tata Memorial Centre in Mumbai along with a Mumbai-based biopharmaceutical company, and is going to begin with phase I and II clinical trials of the M-ASPAR.

The officiating Director, Professor N Jain pointed out that research has always been the forte of the IITs. This is a crucial achievement in the field of medicine as the new enzyme will reduce side effects and the overall cost of treatment- marking a marvel in the treatment of cancer in India. IIT will lend maximum support to the trials until a logical and concrete conclusion is reached.

With mercury dipping to 4.5°C, Lucknow turns colder than Shimla & Dehradun!

As per the forecast by the Indian Meteorological Department, the cold spell, possibly accompanied by thundershowers is set to continue for the next two days in Lucknow

With the intensifying winter chills in Lucknow, the city marked temperatures lower than hill stations like Dehradun and Shimla on Tuesday. The maximum temperature of the city was marked at 12.2°C, which was around 3 degrees lower than that in these hill stations. As per the forecast by the Indian Meteorological Department, the cold spell, possibly accompanied by thundershowers is set to continue for the next two days as well.

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Finals of Syed Modi International 2022 to take place in Lucknow on January 23

The ongoing international badminton competition is taking place at the Babu Banarasi Das Stadium in Lucknow

The finale of the ongoing Syed Modi International 2022 is scheduled to take place on January 23 at the Babu Banarasi Das Stadium in Lucknow. Notably, this international level badminton competition was started on 18 January. After registering a win on Wednesday, Ace Indian shuttler PV Sindhu and the Indian Open finalist Supanida Katethong from Thailand are set to clash in the quarter-finals. Read on to know more about the badminton tournament that is taking place in Lucknow.

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An inspiration for all, THIS 77-year-old 'student' from Rajasthan enrolls for 12 board exams!

Interestingly, this is not the first time Hukumdas has grabbed the limelight for showing dedication towards completing his basic education

With a firm belief in the saying that there is no age limit to learning, 77-year old Hukumdas Vaishnav from Rajasthan is all set to appear for class XII examinations this year. Interestingly, this is not the first time Hukumdas has grabbed the limelight for his dedication towards completing his basic education. Read on to know more about the inspirational real-life story of Jalore's Hukumdas Vaishnav.

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UP Elections 2022: Postal ballot facility to be rolled out for elderlies & COVID patients

Postal ballot box will be provided at homes to ensure that senior citizens, COVID-19 patients and the physically challenged persons are able to cast their votes in with ease

Uttar Pradesh State Election Commission has launched a postal ballot facility to ease matters for citizens. Amid concerns over rising COVID-19 cases, the EC stressed that their first and foremost objective is a 'COVID safe election'. The postal ballot box will be provided at homes to ensure that senior citizens, COVID-19 patients and physically challenged persons are able to cast their votes in with ease while ensuring that no citizen of India is deprived of their universal adult franchise.

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3,517 new cases reported in Lucknow on Wednesday

Nearing the 1-lakh mark, the active caseload in Uttar Pradesh has reached a total of 98,238 cases, as of January 19

With 3,517 new cases reported on Wednesday, the surge in COVID cases continues in Lucknow. This has brought up the total number of active cases in the city to 16,943. According to the daily health bulletin released by the administration, one casualty related to coronavirus was also marked in the city on January 19. Read more to know about the current status of coronavirus in Lucknow and other districts of Uttar Pradesh.

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With the completion of track laying work on the Metro Line 2A and Metro Line 7, the Mumbai Metropolitan Region Development Authority (MMRDA) is all set to start its commercial run for the public of the Mumbai Metropolitan Region soon. While MMRDA has completed the work on Phase 1(Dahanukarwadi and Aarey) of this project, the nodal agency awaits the clearance certificate from the Commissioner of Metro Railway Safety (CMRS) now.

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SGPGI in Lucknow issues fresh guidelines for consultations in OPD & IPD admissions

Apart from the RT-PCR, a negative TrueNat test report of COVID will also be accepted at the time of entry in PGI

In view of the rising COVID cases in the city, the administration of Sanjay Gandhi Post Graduate Institute of Medical Sciences has issued new guidelines for admission in the Outpatient Department(OPD) and Inpatient Department (IPD). As per the new rules, a negative COVID test report is mandatory for those intending to get appointments for consultations with doctors or admission in IPD. Read on to know more about the fresh guidelines now applicable at SGPGI in Lucknow.

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