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Lucknow's SGPGIMS bags Australian patent for study on steroid toxicity

Funded by the Indian Council of Medical Research (ICMR), New Delhi, this study has been registered as an innovation patent for 8 years starting August 16, 2021.

Lucknow's Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) has bagged its first innovative patent from Australia for innovation in the management of childhood Idiopathic Nephrotic Syndrome (NS). Funded by the Indian Council of Medical Research (ICMR), New Delhi, this study has been registered as an innovation patent for the next eight years, starting August 16, 2021.



Around 8000 cases of nephrosis are detected at SGPGIMS, every year

The Commonwealth of Australia has granted an international patent to the nephrology department of SGPGIMS for its study- "A Method to Determine a Steroid-Resistant Phenotype in Childhood Idiopathic Nephrotic Syndrome by Utilising a Pharmacogenomic Biomarkers". As per Prof Narain Prasad, the HoD of Nephrology Department at SGPGI, "As a result of the disease, children lose the heavy amount of protein in the urine and swelling appears all over the body. Gradually, it may lead to kidney failure, requiring dialysis and renal transplantation. The treatment for this disease rests on steroids, but while some children are resistant to steroids since the beginning, many develop resistance during treatment."

Reportedly, around 8,000 cases of nephrosis are reported each year at SGPGI alone. Generally, at least 10 to 20% of children do not respond to steroid therapy. While an average of one-third of the remaining 80% of patients develop steroid resistance after the initial response, the other proportion develops the resistance to steroids in the later stages. According to the HoD, prolonged resistance to steroids leads to a kind of toxicity in the body, which results in various health issues. These problems include frequent infections, weakening of immunity, stunted growth, bone weakness and other metabolic conditions like diabetes and cataract.

Patent valid for the next 8 years

According to the professor, in case of resistance, the body treats steroid like a foreign substance and triggers release of glycoproteins P-gp and MRP-1. These proteins on the body cell surface work like an efflux pump and bloat to prevent penetration of the medicine inside the body. As a consequence, the medicine fails to work and the symptoms start showing up again. Exposing children to tests in order to determine P-gp and MRP-1 levels in blood might be of help, said Prof. Prasad. The study establishing the success of this method has been published in high impact medical journal Nature's publication Pharmacogenomics, added Prasad.

"The challenges became the base for research and evolved into an innovation, which earned the Australian patent. Valid for eight years, the patented method recognised new biomarkers -- called P-gp and MRP-1 in this case -- to identify steroid resistance so that the alternative regimen may be introduced," said the HoD who lead the team for this study.

SGPGI in Lucknow to get a helipad; Air-ambulance service to begin soon!

As per the officials of Sanjay Gandhi Post Graduate Institute, this facility is aimed to boost organ transplant across Uttar Pradesh.

Augmenting the existing medical infrastructure in Uttar Pradesh, Lucknow's Sanjay Gandhi Post Graduate Institute (SGPGI) is all set to start air ambulance services soon. As per the official report, the administration has given a go ahead for this new facility and the construction of helipad is about to begin by 2022 January. Notably, the PGI administration has already filed a detailed project report for this upcoming facility.

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Eternal Hospital in Jaipur performs more than 3000 TAVI/TAVR procedures!

Notably, this path-breaking procedure was performed for the first time in Rajasthan in 2016, at Eternal Hospital.

Adding yet another feather to its cap, Eternal Hospital (EHCC) in Jaipur has managed to perform the highest number of Transcatheter Aortic Valve Implantation(TAVI) and Transcatheter Aortic Valve Replacement (TAVR) procedures in Rajasthan. As per the officials, the hospital has performed this ground-breaking procedure more than 3200 times as of now. Notably, EHCC was also the first hospital in Rajasthan to perform this rare medical feat in the year 2016.

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Goa issues fresh guidelines for travellers in wake of Omicron rise

The new guidelines cover both Domestic and International passengers.

The Goa government has laid down new rules for domestic and international travellers. The tightened security is a result of the rise in cases of the Omicron variant of Covid-19, across the country. Previously, the government had issues guidelines that specifically applied to international passengers from the 12 'high-risk' countries.

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Traffic to remain affected for 3 days in Lucknow on account of 'Swarnim Vijay Varsh' Event

Here's a list of route diversions in Lucknow due to the upcoming 'Swarnim Vijay Varsh Event'

Lucknow's traffic management system has been altered on account of the 'Swarnim Vijay Varsh Event', commemorating the golden Jubilee (50-years) of India's stellar victory during the 1971 Bangladeshi Liberation War. Set to be held at Vidhan Sabha on Thursday, this mega celebration will result in intense roadblocks in the heart of the city. As such, the Lucknow administration has devised two action plans, namely A and B, to avert any traffic inconvenience and regulate vehicular movements with ease. Check all route diversions here:

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Omicron in Rajasthan: 9 people in Jaipur test positive for the new COVID variant!

With 9 cases in Jaipur, Omicron variant of COVID enters Rajasthan!

On Sunday, nine people in Jaipur tested positive for the Omicron variant of COVID19. As per the reports, these residents of the Adarsh Nagar were found positive for the new strain of the novel coronavirus during the genome sequencing of the samples at the Sawai Man Singh Hospital. With these additions in Rajasthan, the cumulative count of this 'variant of concern' in India has reached 21 now.

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Indian Navy unfurls World's Largest National Flag in Mumbai

The exhibit coincides with Navy Day Celebrations

On Saturday, the Western Naval Command exhibited the world's largest national flag at the Naval Dockyard in Mumbai. The flag overlooks the Gateway of India. This move is a part of Navy Day celebrations, and is meant to commemorate Azadi ka Amrit Mahotsav i.e. 75 years since Independence.

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Amid Omicron scare, 5 new patients tested positive for COVID in Lucknow on Sunday

All patients are in home isolation & are being monitored through the COVID Command Centre.

Amid the rising fear of the Omicron variant of COVID-19, 5 new cases of Covid-19 (Older variants) have gripped Lucknow. This new tally includes three cases from the same household and a single independent case from Vibhuti Khand which record an inter-state travel history. Notably, one more case was detected in Indira Nagar. All patients are under home isolation and being monitored through the COVID Command Centre, added reports.

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